Liquid Biopsy: An Emerging Platform for Detecting, Monitoring, and Selecting Therapy for Cancer (C)

Session Description

This session has been identified and designated as Credit to Meet ACS Accreditation/Verification Requirements for Cancer. Learn more about ACS Accreditation/Verification Requirements.

Liquid biopsy measures tumor-derived products in blood and other easily attainable bodily fluids (such as urine, saliva, or tears). Such products include circulating tumor cells (CTCs), circulating endothelial cells, circulating nucleic acids (circulating tumor DNA, ctDNA, or microRNA), tumor-educated platelets, and extracellular vesicles (EVs, of which exosomes are a subpopulation). Liquid biopsy blood or other fluid samples may be obtained serially without entailing the risk of tissue biopsy and may better reflect the spectrum of molecular features defining a patient’s cancer that could be missed with a single core needle tissue biopsy of a heterogeneous tumor. This session will give an overview of the field and then describe areas that may specifically affect future surgical care and oncology practice.

Moderator: Stefanie S. Jeffrey, MD, FACS, Stanford, CA

Co-Moderator: Genevieve M. Boland, MD, PhD, FACS, Boston, MA


Liquid Biopsy—An Overview
Stefanie S. Jeffrey, MD, FACS, Stanford, CA

Whole Transcriptome RNA-Seq of Circulating Tumor Cells in Breast Cancer to Characterize Treatment Opportunities
Julie E. Lang, MD, FACS, Los Angeles, CA

Current and Future Applications of Circulating Tumor DNA in the Management of Lung Cancer
James M. Isbell, MD, FACS, New York, NY

Liquid Biopsy for Pancreas Cancer: Ready for Prime Time?
Jeffrey A. Drebin, MD, PhD, FACS, New York, NY

Utilization of Circulating Extracellular Vesicles for Disease Monitoring in Cancer
Genevieve M. Boland, MD, PhD, FACS, Boston, MA

Panel Discussion: Issues in Implementation of Liquid Biopsy for Clinical Care
Stefanie S. Jeffrey, MD, FACS, Stanford, CA
Genevieve M. Boland, MD, PhD, FACS, Boston, MA

Sponsored by the Scientific Forum Committee

Target Audience

  • Practicing surgeons
  • Residents

Learning Objectives

  • Apply new knowledge and ideas to improve their surgical practice
  • Adapt concepts and quality measures in support of research advancements
  • Enhance the quality of patient care


For questions about the course, please contact

Course summary
Available credit: 
  • 1.50 AMA PRA Category 1 Credit™
  • 1.50 Certificate of Completion
  • 1.50 Self Assessment Credit
Course opens: 
Course expires: 

Disclosure Information

In accordance with the ACCME Accreditation Criteria, the American College of Surgeons must ensure that anyone in a position to control the content of the educational activity (planners and speakers/authors/discussants/moderators) has disclosed all relevant financial relationships with any commercial interest. For additional information, please visit the ACCME website.

The ACCME also requires that ACS manage any reported conflict and eliminate the potential for bias during the educational activity. Any conflicts noted below have been managed to our satisfaction. The disclosure information is intended to identify any commercial relationships and allow learners to form their own judgments. However, if you perceive a bias during a activity, please report it on the evaluation.

(Download the full list of disclosures).

Faculty and Disclosures

Genevieve M. Boland, MD, PhD, FACS - Novartis: Honorarium: Speaker; NW Biotherapeutics: Honorarium: Consulting; Takeda Oncology: Sponsored Research Agreement: Co-PI
James M. Isbell, MD, FACS - LumaCyte, Inc.: Stockholder
Jeffrey A. Drebin, MD, PhD, FACS - Alnylam Pharmaceuticals: Equity shares: Stock holder (via brokerage purchase); American Regent/Luitpold Pharmaceuticals: Spouse is an employee; Ionis Pharmaceuticals: Equity shares: Stock holder (via brokerage purchase)
Julie E. Lang, MD, FACS - ANGLE Parsortix: Research contract to my institution: PI; Genomic Health: Honorarium: Speaker Bureau
Stefanie S. Jeffrey MD, FACS - Nothing to Disclose

Program Committee and Disclosures

CHAIR: Henri R. Ford, MD, MHA, FACS, FAAP, FRCSEng(Hon), Miami, FL - Nothing to Disclosure
VICE-CHAIR: David T. Cooke, MD, FACS, Sacramento, CA - Nothing to Disclosure


David C. Borgstrom, MD, FACS, Morgantown, WV - Nothing to Disclosure
Daniel L. Dent, MD, FACS, San Antonio, TX - Nothing to Disclosure
Roger R. Dmochowski, MD, FACS, Nashville, TN - Allergen: Honoraria: Consultant
Cynthia D. Downard, MD, FACS, Louisville, KY - Nothing to Disclosure
Audra A. Duncan, MD, FACS, London, ON - Nothing to Disclosure
Mariam F. Eskander, MD, Boston, MA - Nothing to Disclosure
Paula Ferrada, MD, FACS, Richmond, VA - Nothing to Disclosure
Neil H. Hyman, MD, FACS, Chicago, IL - Nothing to Disclosure
Martin S. Karpeh, Jr., MD, FACS, New York, NY - Nothing to Disclosure
Dennis H. Kraus, MD, FACS, New York, NY - Nothing to Disclosure
Kenneth W. Sharp, MD, FACS, Nashville, TN - Nothing to Disclosure


Daniel M. Herron, MD, FACS, FASBMS, New York, NY - Nothing to Disclosure
Edith Tzeng, MD, FACS, Pittsburgh, PA - Nothing to Disclosure


Barbara Lee Bass, MD, FACS, FRCSEng(Hon), FRCSI(Hon), FCOSECSA(Hon), Houston, TX - Nothing to Disclosure
Quan-Yang Duh, MD, FACS, San Francisco, CA - Nothing to Disclosure
B. J. Hancock, MD, FACS, FRCSC, Winnipeg, MB - Nothing to Disclosure
Ronald V. Maier, MD, FACS, FRCSEd(Hon), Seattle, WA - Nothing to Disclosure

Continuing Medical Education Credit Information


The American College of Surgeons is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA PRA Category 1 Credits™

The American College of Surgeons designates this enduring activity for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Of the AMA PRA Category 1 Credits™ listed above, a maximum of 1.5 credits meets the requirements for Self-Assessment.

American College of Surgeons and ACGME Logos

Note: Residents will receive a Certificate of Completion.

Available Credit

  • 1.50 AMA PRA Category 1 Credit™
  • 1.50 Certificate of Completion
  • 1.50 Self Assessment Credit
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This course is available as part of the Clinical Congress 2019 Webcast Packages