CC2019: I.S. Ravdin Lecture in the Basic and Surgical Sciences
Response to Injury: The Genomic Storm and Precision Medicine
Presiding Officer and Introducer: Amy L. Halverson, MD, FACS, FASCRS, Chicago, IL
Lecturer: Ronald V. Maier, MD, FACS, FRCSEd(Hon), FCSHK(Hon), FCCS(Hon), Seattle, WA
Patients who survive massive trauma often fare poorly. Many patients heal slowly, develop surgical infections, pneumonia, urinary tract infections, and multiple other problems that do not appear to be directly related to their trauma. Research suggests that the root cause is not their physical injuries, but rather their genomic response to their injuries.
Of 20,000-plus genes examined in a study of patients who survived motor vehicle collisions, more than 16,000 genes (80 percent) showed a measurable change of function following blunt trauma. About a third of the genes—most of them associated with inflammatory processes that potentially lead to kidney failure, pulmonary dysfunction, and other tissue damage—are upregulated. Two-thirds are down-regulated following trauma, primarily affecting the adaptive immune response, according to the study, which was published in the Journal of Experimental Medicine in 2011.
Dr. Maier discusses genomic responses to trauma during Monday afternoon’s I.S. Ravdin Lecture in the Basic and Surgical Sciences, Response to Injury: The Genomic Storm and Precision Medicine. Dr. Maier is surgeon-in-chief, Harborview Medical Center, Seattle, and the Jane and Donald D. Trunkey Professor of Trauma Surgery, University of Washington School of Medicine.
This annual lecture has been sponsored by the I.S. Ravdin Surgical Society since 1964 to honor Dr. Ravdin by promoting knowledge in basic sciences with application to surgery.
In accordance with the ACCME Accreditation Criteria, the American College of Surgeons must ensure that anyone in a position to control the content of the educational activity (planners and speakers/authors/discussants/moderators) has disclosed all relevant financial relationships with any commercial interest. For additional information, please visit the ACCME website.
The ACCME also requires that ACS manage any reported conflict and eliminate the potential for bias during the educational activity. Any conflicts noted below have been managed to our satisfaction. The disclosure information is intended to identify any commercial relationships and allow learners to form their own judgments. However, if you perceive a bias during a activity, please report it on the evaluation.
(Download the full list of disclosures).
Faculty and Disclosures
Amy L. Halverson, MD, FACS, FASCRS - Nothing to Disclose
Ronald V. Maier, MD, FACS, FRCSEd(Hon), FCSHK(Hon), FCCS(Hon) - Nothing to Disclose
Program Committee and Disclosures
CHAIR: Henri R. Ford, MD, MHA, FACS, FAAP, FRCSEng(Hon), Miami, FL - Nothing to Disclosure
VICE-CHAIR: David T. Cooke, MD, FACS, Sacramento, CA - Nothing to Disclosure
David C. Borgstrom, MD, FACS, Morgantown, WV - Nothing to Disclosure
Daniel L. Dent, MD, FACS, San Antonio, TX - Nothing to Disclosure
Roger R. Dmochowski, MD, FACS, Nashville, TN - Allergen: Honoraria: Consultant
Cynthia D. Downard, MD, FACS, Louisville, KY - Nothing to Disclosure
Audra A. Duncan, MD, FACS, London, ON - Nothing to Disclosure
Mariam F. Eskander, MD, Boston, MA - Nothing to Disclosure
Paula Ferrada, MD, FACS, Richmond, VA - Nothing to Disclosure
Neil H. Hyman, MD, FACS, Chicago, IL - Nothing to Disclosure
Martin S. Karpeh, Jr., MD, FACS, New York, NY - Nothing to Disclosure
Dennis H. Kraus, MD, FACS, New York, NY - Nothing to Disclosure
Kenneth W. Sharp, MD, FACS, Nashville, TN - Nothing to Disclosure
Daniel M. Herron, MD, FACS, FASBMS, New York, NY - Nothing to Disclosure
Edith Tzeng, MD, FACS, Pittsburgh, PA - Nothing to Disclosure
Barbara Lee Bass, MD, FACS, FRCSEng(Hon), FRCSI(Hon), FCOSECSA(Hon), Houston, TX - Nothing to Disclosure
Quan-Yang Duh, MD, FACS, San Francisco, CA - Nothing to Disclosure
B. J. Hancock, MD, FACS, FRCSC, Winnipeg, MB - Nothing to Disclosure
Ronald V. Maier, MD, FACS, FRCSEd(Hon), Seattle, WA - Nothing to Disclosure
A Certificate of Completion will be awarded.
This educational activity is not eligible for CME or CE credits.